首先我们来看下talk to sb和talk with sb的大致意思：
talk to sb：词性为动词短语，talk to sb表示主动地与某人对话或谈话。
talk with sb：词性为动词短语，talk with sb表示与某人进行互动对话或交流
通过下面的表格我们了解下talk to sb和talk with sb的含义、发音和用法
接下来让我们看下talk to sb和talk with sb的用法区别：
1.语法角度：talk to sb中的to是一个介词，后面接人称代词或名词，表示向某人传达信息或交流意见；而talk with sb中的with是一个介词，后面接人称代词或名词，表示与某人进行对话或交流。
例子：
- I need to talk to the teacher.
(我要去跟老师谈一谈。)
- She is talking with her friends.
(她正在和朋友交谈。)
2.语气角度：talk to sb的语气更加正式和权威，有时可能不太友好或命令性；而talk with sb的语气更加轻松和友好，更多用于平等或非正式的交流。
例子：
- You should talk to your boss about this issue.
(你应该去和你的上司谈谈这个问题。)
- Can we sit down and talk with each other?
(我们可以坐下来谈谈吗？)
3.信息传递角度：talk to sb更强调向某人传达特定的信息、指示或建议；而talk with sb更强调双方之间的互动和交流。
例子：
- I need to talk to the doctor about my condition.
(我需要去和医生谈一谈我的病情。)
- I enjoy talking with my friends.
(我喜欢和朋友聊天。)
4.目的角度：talk to sb通常用于表达某种目的或目标，如传达消息、指示或请求；而talk with sb则更倾向于进行对话、交流或讨论特定的话题。
例子：
- I need to talk to him about the future plans.
(我需要找他谈一谈未来的计划。)
- I want to talk with you about the recent news.
(我想跟你聊聊最近的新闻。)
talk with sb 和 talk to sb 有释义、侧重点及句型结构三个区别：
1、释义不同。
talk to sb意为：对某人讲话，还有责骂某人的意思。
talk with sb意为：某人一起交谈，还含有想说服某人的意思。
2、侧重点不同。
talk to sb 有点命令或者是告诉的意思，强调谈话的对象是“单向的”，如：I am talking to Tom.强调我单方面的对汤姆在谈话。
talk with sb 侧重两个人的一起互动，强调谈话的对象是 “双向的”，如：I am talking with Tom.强调我和汤姆在相互谈话、交流。
3、句型结构不同。
talk to sb一般会跟从句，如 I could always talk to you about anything in the world.（我总是可以和你谈论世界上的任何事情。）
talk with sb一般用在简单句，如I want to have a talk with him alone. （我想和他单独谈谈。）
参考资料：百度百科-talk
本回答被网友采纳talk with sb和talk to sb的区别如下：
1、释义不同。
talk to sb意为：对某人讲话；talk with sb意为：某人一起交谈。
2、侧重点不同。
talk to sb表示一个人要对另一个人讲话，但是不表示对方也需要讲话，主要是强调告诉某人什么事；
talk with sb表达的是和某人一起谈论什么事物，双方都要发表言论，相互沟通。
3、句型结构不同。
talk with sb一般用在简单句；talk to sb一般会跟从句。
例句：
1、I want to have a talk with him alone.我要和他单独谈一谈。
2、I'll need to talk with you, but there's no hurry.我得和你谈谈，但不着急。
3、Before the wedding, I had a heart-to-heart talk with my mother.婚礼前，我和母亲好好谈了谈心。
4、One child shrinks away from me when I try to talk to him.当我试图和一个孩子说话时，他避开了我。
5、How many times has your mother told you never to talk to strangers?你母亲告诉你多少次了，绝不能和陌生人谈话？
6、If you happen to talk to him, have him call me.如果你碰巧能和他说话，让他给我打个电话。
talk to sb 和talk with sb的区别如下所示。
1. 释义区别：
talk to sb：向某人说话，表示单向的沟通，一方向另一方传递信息。
talk with sb：与某人交谈，表示双向的对话，双方互相交流信息。
例句：
Can I talk to you about a personal matter?（我能跟你谈谈个人问题吗？）
Let's talk with our team members and get their input.（我们与团队成员交流一下，听听他们的意见。）
2. 用法区别：
talk to sb：常用于一对一的沟通，或者一个人对多个人的沟通。
talk with sb：常用于双向交流或团体讨论。
例句：
The teacher talked to the student after class.（老师下课后和学生单独交谈。）
We need to talk with the whole team to make a decision.（我们需要与整个团队讨论，做出决策。）
3. 使用环境区别：
talk to sb：适用于较正式的场合，一方向另一方传递信息。
talk with sb：更通用，适用于正式或非正式的场合，双方进行交流。
例句：
He talked to the CEO about his career development.（他和首席执行官谈了谈他的职业发展。）
She talked with her friend about their weekend plans.（她和朋友讨论了周末的计划。）
4. 影响范围区别：
talk to sb：强调信息的传递，着重在单方面与某人交谈。
talk with sb：强调双向交流，重点在于与某人进行对话。
例句：
I need to talk to the manager to get more details.（我需要与经理交谈，以获取更多细节。）
Let's talk with our customers to understand their needs.（让我们与客户交流，了解他们的需求。）
5. 形象区别：
talk to sb：更倾向于指示或传达信息的行为。
talk with sb：更倾向于开放性的对话或交谈。
例句：
The doctor talked to the patient about their treatment options.（医生向患者介绍了他们的治疗选择。）
She enjoyed talking with her colleague at the office party.（她喜欢在办公室聚会时与同事交谈。）
首先我们来看下talk to sb、talk with sb的大致意思
talk to sb：词性为短语动词，talk to sb是指向某人说话或与某人交流。其中to是介词，表示目标。talk to sb强调的是发出信息的一方。
talk with sb：词性为短语动词，talk with sb也是指与某人说话或交流。with是介词，表示陪同、伴随。talk with sb强调的是双方的交流对话。
通过下面的图我们了解下talk to sb、talk with sb的含义、发音和用法
接下来我们讲解几个用例，希望这些用例可以加深您的理解
talk to sb：
I need to talk to the teacher.
(我需要去和老师交谈一下。)
He is talking to the client.
(他正在和客户交谈。)
She decided to talk to his parents.
(她决定与他父母好好谈谈。)
Please talk to me.
(请你和我说话。)
They are talking to experts about this issue.
(他们正在与专家讨论这个问题。)
I want to talk to you about this plan.
(我想与你谈谈这个计划。)
talk with sb：
I want to talk with you about this issue.
(我想和你交谈一下这个问题。)
They are talking with the senior management.
(他们正在与高层管理层进行会谈。)
Please talk with me about this plan.
(请你和我一起讨论这个计划。)
She likes to talk with her friends.
(她喜欢与朋友们畅所欲言。)
They are talking with each other while having coffee in the cafe.
(他们在咖啡馆里边喝咖啡边聊天。)
I hope to talk with the experts about this topic.
(我希望能与专家讨论一下这个课题。)