首先我们来看下despite和despite of的大致意思：
despite：词性为介词，表示不管、不顾、不论某种情况的存在
despite of：词性为介词短语，表示不管、不顾、不论某种情况的存在
通过下面的表格我们了解下despite和despite of的含义、发音和用法
接下来让我们看下despite和despite of的用法区别：
1.词组构成：despite是单词，despite of是介词短语
例子：
- Despite his hard work, life didn't get better.
(尽管他努力工作，但生活并没有变得更好。)
- Despite being told not to eat too much sugar, they still ate a lot.
(尽管他们被告知不要吃太多糖，但他们还是吃了很多。)
2.结构：despite后面接名词或名词短语，despite of后面接名词性物主代词或动名词
例子：
- Despite her busyness, she still maintains a healthy lifestyle.
(尽管她的忙碌，她仍然保持了健康的生活方式。)
- Despite the cold weather, he went for a run.
(尽管天气寒冷，他还是去跑步锻炼了。)
3.否定形式：despite可以直接接句子的否定形式，despite of需要在of后面加上not才能接句子的否定形式
例子：
- Despite his lack of experience, he bravely accepted the challenge.
(尽管他没有经验，他还是勇敢地接受了挑战。)
- Despite of her not liking swimming, she still participated in the competition.
(尽管她不喜欢游泳，她还是参加了比赛。)
4.形式：despite后面不需要使用介词of，而despite of需要使用介词of
例子：
- Despite his efforts, he didn't receive the recognition he deserved.
(尽管他的努力，他没有得到应有的认可。)
- Despite her concerns, she decided to stick to her decision.
(尽管她的担忧，她决定坚持自己的选择。)