3.6. Effect of ARP on the OVA-specific serum antibody response in vivo
The effect of ARP on the induction of humoral immune response
in OVA immunized mice was evaluated. As shown in Fig. 5, ARP
(200, 400 and 800 lg) significantly enhanced the OVA-specific serum
IgG2a and IgG2b antibody levels, as compared with control
group (p < 0.01), especially at a dose of 400 lg. Among the T lymphocytes, helper T cells induce B lymphocytes to secrete antibodies. Help T cells can be divided into two subsets of effector cells,namely Th1 and Th2 cells. The Th1 cells secrete cytokines, such
as interleukin-2 (IL-2), tumor necrosis factor-b (TNF-b) and interferon-
c (IFN-c), and stimulate the production of IgG2a, IgG2b
and IgG3 in mice. They are responsible for cytotoxic T lymphocyte
(CTL) production. The Th1 response against intracellular pathogens
and malignant cells is superior to the Th2 response (Constant &
Bottomly, 1997; Del Prete, De Carli, Ricci, & Romagnani, 1991;
Fiorentino, Bond, & Mosmann, 1989). Thus, from the above findings
we can draw a conclusion that ARP at suitable dose can enhance
serum antibody production, and tilt the immune system in favor
to Th1 type response in mice immunized with OVA.
哪位高手先帮忙翻译下在此先谢了