可以通过手机中支付宝APP中的安全设置来注销支付宝账户。具体操作步骤如下：
1、在手机的主页中查找支付宝APP，点击打开支付宝APP进入支付宝主界面。
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2、在打开的支付宝首页的右下方找到“我的”图形标志，点击进入支付宝“我的”主页面。
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3、在支付宝“我的”界面选择右上方的设置功能选项，点击进入支付宝设置功能界面。
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4、在支付宝设置功能界面选择安全设置，点击进入到支付宝安全设置界面。
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5、在支付宝安全设置界面选择安全中心选项，点击进入支付宝的安全中心界面。
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6、在支付宝的安全中心界面选择下方的永久注销账户选项，点击进入到支付宝账户注销界面。
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7、在支付宝账户注销界面点击下一步进入到注销支付宝账户的确认界面。
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8、在注销支付宝账户的确认界面输入支付宝支付密码进行账户的确认验证。
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9、确认账户信息无误并输入支付密码后，点击下方确认注销按钮即可完成支付宝账户永久注销的操作。
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