■ 艾滋病病毒基础研究；病毒表位疫苗作用机理研究；重组表位疫苗的设计与应用基础研究
Selected Publications:
■ Huang JH, Lu L, Lu H, Chen X, Jiang S, Chen YH. Identification of the HIV-1 gp41 core-binding motif in the scaffolding domain of caveolin-1. Journal of Biological Chemistry. 2007, 282: 6143–6152.
■ Dong XN, Chen YH. Marker vaccine strategies and candidate CSFV marker vaccines. Vaccine. 2007, 25 (2): 205-230
■ Huang JH, Yang HW, Liu S, Jiang S, Chen YH. The mechanism by which molecules containing the HIV-1 gp41 core-binding motif HXXNPF inhibit HIV-1 envelope glycoprotein-mediated syncytium-formation. Biochemical Journal. (Published on 16 Jan 2007)
■ J.H. Huang, Z.Q. Liu, S. Liu, S.Jiang, Y.H. Chen. Identification of the HIV-1 gp41 core-binding motif-HXXNPF. FEBS Letters. 2006, 580:4807-4814
■ Dong XN, Chen YH. Strategies for mapping neutralizing epitopes: One way and two sides. Vaccine. 2006, 24 (22): 4689-4691
■ Dong XN, Chen YH. Spying the neutralizing epitopes on E2 N-terminal by candidate epitope-vaccines against classical swine fever virus. Vaccine. 2006 24 (19): 4029-4034
■ Dong XN, Qi Y, Ying J, Chen YH. Candidate peptide-vaccine induced potent protection against CSFV and identified a principal sequential neutralizing determinant on E2.Vaccine 2006, 24: 426-434
■ Wanli Liu, Ying-Hua Chen. High epitope density in single protein molecule significantly enhanced antigenicity as well as immunogenicity: a novel strategy for modern vaccine development and a preliminary investigation about B cell discrimination of monomeric proteins. European Journal of Immunology. 2005, 35:505-14.
■ Wanli Liu, Peng Zou, Jian Ding, Yun Lu, Ying-Hua Chen. Sequence comparison of the extracellular domain of M2 protein between human and avian influenza a virus provides new information for bivalent influenza vaccine design. Microbes Infect. 2005, 7:171-177
■ Dong XN, Chen X, Chen Y, Ablimit A, Ye Z, Wu Y, Ying-Hua Chen. Short Communication: HIV Type 1 Phenotype, Tropism, and Sequence Patterns: Association and Preference. AIDS Res Hum Retroviruses. 2005, 21:234-8
