求助~请哪位高手帮忙翻译这段话,谢谢谢谢

DNA methylation is a heritable and stable epigenetic mark associated with transcriptional repression.Changes in the patterns and levels of global and regional DNA methylation regulate development and contribute directly to disease states such as cancer. Recent findings provide intriguing insights into the epigenetic crosstalk between DNA methylation, histone modifications, and small interfering RNAs in the control of cell development and carcinogenesis. In this review, we summarize the recent studies in DNA methylation primarily focusing on the interplay between different epigenetic modifications and their potential role in gene silencing in development and disease. Although the molecular mechanisms involved in the epigenetic crosstalk are not fully understood, unraveling their precise regulation is important not only for understanding the underpinnings of cellular development and cancer, but also for the design of clinically relevant and efficient therapeutics using stem cells and anticancer drugs that target tumor initiating cells.
很着急要啊~谢谢,谢谢好心人了
我没有多的财富值,只有这么点了,才加入知道,好心人不要在意,帮帮忙吧,很着急,万分感谢

第1个回答  2010-04-09
这篇文章太复杂了,我翻译到 control of cell development and carcinogenesis. In this review,
没有信心翻下去,如果需要继续翻的话 请hi我
很想帮到你

DNA甲基化是一个和转录阻遏有联系的可遗传的和稳定的遗传外标记。在整体形式和标准的改变和区域的DNA甲基化管理发展和直接对疾病的状况如癌症的起作用。最近的发现证明了有着有趣的洞察在DNA甲基化,组蛋白修饰和短片段双链核糖核酸在细胞发展和致癌的控制中。
第2个回答  2010-04-09
DNA甲基化是表观遗传标记遗传稳定的模式和在全球和区域DNA甲基化水平的相关调节转录repression.Changes发展,直接促进癌症等疾病状态。最近的调查结果可为与DNA甲基化,组蛋白修饰后生相声有趣的见解,
和小分子干扰在细胞癌化的发展和控制的RNA。在这篇综述中,我们总结了在DNA甲基化的最新研究主要根据不同表观遗传修饰及其潜在的作用,在发展和疾病的基因沉默的相互作用为重点。虽然米
在后生串扰涉及olecular机制尚不完全清楚,解开他们的精确调控是重要的,不仅对了解细胞和癌症发展的基础,而且为临床相关设计和高效利用干细胞疗法和抗癌药物靶肿瘤起始细胞。
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